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Elucidating mechanism cellular uptake removal

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This work evaluates the uptake mechanism of MRC NPs in metastatic and nonmetastatic breast cancer-cell models, comparing them to a nontumor cell line.

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Current studies with maghemite (an iron oxide compound) NPs have demonstrated in vitro- and in vivo-specific cytotoxic action for target cells, indicating these NPs are a promising option for drug delivery.

Nanoscale particles of gold nowadays dominate a great deal of attention for biomedical applications.

Better knowledge of the nano-bio interface will lead to advanced biomedical tools for diagnostic imaging and therapeutics.

Moreover, this process occurred through a clathrin-dependent endocytosis pathway with different basal expression levels of this protein in the cell lines tested.

Keywords: maghemite, nanomaterials, cells uptake, endocytosis Iron oxide nanoparticles (NPs) hold great promise as diagnostic and therapeutic agents in oncology.